Postdoctoral Fellowship, Neural and Cardiovascular Physiology, University of Minnesota, 2018
Ph.D., Human Physiology, University of Oregon, 2014
B.S., Biochemistry and Molecular Biology; Cell and Molecular Biology, University of Minnesota Duluth, 2010
B.A., Chemistry, University of Minnesota Duluth, 2011
Throughout my career, I have focused on the physiological underpinnings of the etiology and treatment of high blood pressure (i.e. hypertension). While hypertension is a multi-faceted disease, I have focused my research primarily on neural (brain) and renal (kidney) contributions to the development and maintenance of hypertension. This was motivated, in part, by recent reports that it is now possible to perform targeted nerve ablation of renal nerves in humans, which mitigates or even reverses drug-resistant hypertension. Unfortunately, the mechanisms mediating these beneficial effects are unclear. Thus, our studies aim to elucidate the detailed mechanisms of renal nerves in hypertension to provide a translational platform for development and refinement of emerging antihypertensive therapies.
Research Funding Grants:
R00HL141650, National Institutes of Health (NHLBI)
1. Banek CT, Knuepfer MM, Foss JD, Fiege JK, Asirvatham-Jeyaraj N, Van Helden D, Shimizu Y, Osborn JW. Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension. Hypertension. 2016 Dec;68(6):1415-1423. PubMed PMID: 27698066.
2. Banek CT, Gauthier MM, Baumann DC, Van Helden D, Asirvatham-Jeyaraj N, Panoskaltsis-Mortari A, Fink GD, Osborn JW. Targeted Afferent Renal Denervation Reduces Arterial Pressure but not Renal Inflammation in Established DOCA-salt Hypertension in the Rat. Am J Physiol Regul Integr Comp Physiol. 2018 314(6):R883-R891. PubMed PMID: 29513561.
3. Osborn JW, Banek CT. Catheter-Based Renal Nerve Ablation as a Novel Hypertension Therapy: Lost, and Then Found, in Translation. Hypertension. 2018 Mar;71(3):383-388. PubMed PMID: 29295850.
4. Banek CT, Gauthier MM, Van Helden D, Fink GD, Osborn JW. Renal Inflammation in DOCA-Salt Hypertension: Role of Renal Nerves and Arterial Pressure. Hypertension. 2019 73(5):1079-1086. PubMed PMID: 30879356.