As associate vice president for translational health sciences, Dr. Jason X.-J. Yuan is responsible for leading the development of impactful and sustainable translational health strategies. He also oversees efforts to improve and expedite the conduct of AHSC research and create nurturing research environments for training physician-scientists.
Dr. Yuan is also on faculty at the College of Medicine – Tucson as a professor of medicine, with a joint appointment as professor of physiology.
As a physician-scientist, Dr. Yuan’s research interests include pulmonary vascular pathophysiology and pathogenic mechanisms of pulmonary vascular disease, including idiopathic pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension, pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), interstitial pulmonary fibrosis, obstructive sleep apnea, sickle cell disease and scleroderma.
Dr. Yuan has previously held appointments as professor of medicine and pharmacology, vice chair for scholarly activities for the Department of Medicine, director of the Pulmonary Hypertension Translational Research Program in the Institute for Personalized Respiratory Medicine, and director of the Program in Pulmonary Vascular Disease and Right Heart Function in the Center for Cardiovascular Research at the University of Illinois at Chicago. He also has held faculty positions in the Department of Medicine, School of Medicine, University of California, San Diego, and the Department of Physiology, University of Maryland School of Medicine, Baltimore.
Dr. Yuan’s professional memberships include the American Thoracic Society and he is an elected member of the Association of American Physicians and the American Society for Clinical Investigation. He also is a fellow of the American Heart Association, American Physiological Society and American Association for the Advancement of Science. He has served as adviser and reviewer with many national and international associations, including the National Institutes of Health, Department of Veterans Affairs Medical Center and National Science Foundation. He also was a member of the 2012 review panel of the site visit of the Integrative Cardiac Health Program at Walter Reed Army Institute of Research, American Institute for Biological Sciences and Telemedicine and Advanced Technology Research Center (TATRC) of the Department of Defense.
He has been an invited lecturer at conferences and a visiting lecturer at institutions around the world. He is the recipient of numerous honors and awards, including an American Heart Association Established Investigator Award, a Pulmonary Vascular Research Institute Achievement Award and a 2008 Guggenheim Fellowship Award. He is co-holder of a patent, “Regulating Expression of Transient Receptor Potential Channel Genes,” with C.V. Remillard, L.J. Rubin and Y. Yu.
Selected publications and editorial roles
He is co-editor with Dr. Joe G. N. "Skip" Garcia, C.A. Hales, S. Rich, S.L. Archer and J.B. West of the Textbook of Pulmonary Vascular Disease (2011, Springer) and is the author of numerous books and book chapters and more than 190 scientific journal articles. His articles in the American Journal of Physiology (AJP)-Lung Cellular and Molecular Physiology are among the top 10 cited articles for 1990-1999 and 2000-2011, and also are among the top 10 cited articles for 2000-2011 in AJP-Heart and Circulatory Physiology. He is editor-in-chief of Pulmonary Circulation, deputy editor and associate editor of the American Journal of Physiology Cell Physiology and section editor of Vascular Diseases of the Lung in PanVascular Medicine (2nd edition). He serves on the editorial boards of the American Journal of Physiology Lung Cellular and Molecular Physiology, American Journal of Respiratory and Critical Care Medicine, American Journal of Physiology Heart and Circulatory Physiology, and Circulation Research.
"Pathogenic mechanisms of pulmonary vascular disease; ion channel electrophysiology; and Ca2+ signaling"