Physiology PI Maya Kaelberer publishes new paper in 'Nature'!
A gut sense for gut sensing
Model for microbial pattern sensing by neuroepithelial circuits to drive behavioural change. Bacterial flagellin is detected by TLR5 in colonic PYY-labelled cells, which in turn release PYY to activate vagal neurons through Y2R. Activation of this circuit contributes to overall food intake.
A study recently published in Nature describes a “previously unrecognized” sense that facilitates communication between the gut and the brain.
Co-senior authors M. Maya Kaelberer, PhD, assistant professor of physiology at the University of Arizona College of Medicine – Tucson, and Diego V. Bohórquez, PhD, associate professor of medicine at Duke University, call it the “neurobiotic sense” – or, more simply, the “gut sense.” They place it alongside the “classic” five senses we learn about as children. Read the full news article.