Erika D Eggers, PhD

  • Associate Department Head, Research - Physiology
  • Member of the Graduate Faculty
  • Professor, BIO5 Institute
  • Professor, Biomedical Engineering
  • Professor, Neuroscience - GIDP
  • Professor, Physiological Sciences - GIDP
  • Professor, Physiology
Research Interests: 

The broad goal of research in our laboratory is to understand how inhibitory inputs influence neuronal signaling and sensory signal processing in the healthy and diabetic retina.  Neurons in the brain receive inputs that are both excitatory, increasing neural activity, and inhibitory, decreasing neural activity.  Inhibitory and excitatory inputs to neurons must be properly balanced and timed for correct neural signaling to occur.

To study sensory inhibition we use the retina, a unique preparation which can be removed intact and can be activated physiologically, with light, in vitro.  Thus using the retina as a model system, we can study how inhibitory synaptic physiology influences inhibition in visual processing. This intact system also allows us to determine the mechanisms of retinal damage in early diabetes.

Select Publications

Flood MD, Moore-Dotson JM, Eggers ED. "Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells." J. Neurophysiol.. 2018;120(2):867-879. PMCID: PMC6139461  PMID: 29847232
Moore-Dotson JM, Beckman JJ, Mazade RE, et al. "Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling." Invest. Ophthalmol. Vis. Sci.. 2016;57(3):1418-30. PMCID: PMC4819579  PMID: 27028063
Mazade RE, Eggers ED. "Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling." J. Neurophysiol.. 2016;115(6):2761-78. PMCID: PMC4922601  PMID: 26912599