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Jing-Ping Lin, PhD

Assistant Professor, Physiology
Assistant Professor, Neurology
Jing-Ping Lin, PhD
AHSC 4129

Links

Lab Website
Research Interests

Our group studies how glial cells and their networks keep the brain healthy—and what happens when these systems break down in development, aging, and inflammation. Right now, we are investigating how white matter dynamics shape glial function in preclinical models of multiple sclerosis. Combining neuroimaging, digital histopathology, and spatial omics to perform cross-species comparisons, we aim to uncover the mechanisms that drive myelin damage and repair, paving the way for better diagnosis and treatment of brain disorders.

Publication Highlights
Lin JP, Brake A, Donadieu M, Lee A, Smith G, Hu K, Nair G, Kawaguchi R, Sati P, Geschwind DH, Jacobson S, Schafer DP, Reich DS. 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions. Science. 2025 Feb 28;387(6737):eadp6325. doi: 10.1126/science.adp6325. Epub 2025 Feb 28. PubMed PMID: 40014701.

Lin JP, Kelly HM, Song Y, Kawaguchi R, Geschwind DH, Jacobson S, Reich DS. Transcriptomic architecture of nuclei in the marmoset CNS. Nat Commun. 2022 Sep 21;13(1):5531. doi: 10.1038/s41467-022-33140-z. PubMed PMID: 36130924; PubMed Central PMCID: PMC9492672.

Lin JP, Mironova YA, Shrager P, Giger RJ. LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair. Elife. 2017 Dec 18;6. doi: 10.7554/eLife.30498. PubMed PMID: 29251594; PubMed Central PMCID: PMC5752207.

Full Publication List

Work Experience

  • 2025 Research fellow, NINDS, NIH, Bethesda, MD, USA

Degrees

  • 2018 PhD, University of Michigan Medical School, Ann Arbor, MI, USA
  • 2012 MS, National Taiwan University, Taipei, Taiwan
  • 2008 BS, National Taiwan University, Taipei, Taiwan