Jose F. Ek Vitorin, PhD

My research is focused on the study of Connexins (Cx), integral proteins that form transmembrane channels between cells and with the exterior. Connexin are critical in intercellular signaling and coordination of cell function, like in the transmission of electrical action potentials in the heart. After exploring the regulation of connexin channels by voltage, acidification and phosphorylation, my data produced two distinct models of connexin channel function. Currently, I am exploring the functional links between connexin channels and ionic channels involved in sensing mechanical stimulus, and also continue investigating other modes of channel regulation, i.e., nitrosylation, which may be part of the cardiovascular response to stress.