Nicholas A. Delamere, PhD
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Dr. Delamere is best known for his work on cellular specializations in the eye. His laboratory studies the way Na, K-ATPase works as a sodium ion pump and how it interacts with protein kinases that relay messages and with cell sensors that detect mechanical distortion. Currently he and his colleagues are interested in three ion channels, TRPV1, TRPV4 and Piezo1, that operate as sensors of plasma membrane shrinkage or swelling. Studying these interactions will lead to a better understanding of disease progression in cataract and glaucoma.
Degree(s)
- 1973 BSc Biological Science - University of East Anglia, Norwich, UK
- 1976 PhD Biological Science/Biophysics - University of East Anglia, Norwich, UK
Shahidullah M. and Delamere N.A. (2022) Activation of Piezo1 increases Na,K-ATPase-mediated iontransport in mouse lens. Int. J. Mol. Sci. 23:12870 PMCID: PMC9656371
Delamere, N.A., Shahidullah M., Mathias R.T., Gao J., Sun X., Sellitto C. and White T.W. (2020) Signalingbetween TRPV1/TRPV4 and intracellular hydrostatic pressure in the mouse lens. Invest. Ophthalmol. Vis.Sci. 61:58 PMCID: PMC7415899
Shahidullah M., Mandal A., Wei, G., and Delamere N.A. (2014) Nitric oxide regulation of Na,K-ATPaseactivity in ocular ciliary epithelium involves Src family kinase. J. Cell Physiol. 229: 343-352. PMID:24037816