Ralph F Fregosi, PhD

  • Member of the Graduate Faculty
  • Professor, Evelyn F McKnight Brain Institute
  • Professor, Neurobiology
  • Professor, Neuroscience - GIDP
  • Professor, Physiological Sciences - GIDP
  • Professor, Physiology

EducationUniversity of Massachusetts-Boston, Boston, MA.,1976 ( B.S., Biological Science)The University of Arizona, Tucson, AZ, 1977 (M.S., Exercise PhysiologyThe University of Wisconsin-Madison, Madison, WI, 1985 (Ph.D., Respiratory Physiology)Dartmouth Medical School, Hanover, NH, 1986-1988 (Postdoctoral, Respiratory Physiology)Honors & AwardsPre-Doctoral Fellow of the American Heart Association, 1984-1986Individual National Research Service Award, National Heart, Lung and Blood Institute (IF32 HL 07293), 1986-1988American Heart Association Post-Doctoral Fellowship, 1986 (grant was withdrawn due to concurrent NIH funding)FIRST award, National Heart, Lung and Blood Institute, 1990-95Major Areas of Research Interest NeurophysiologyRespiratory PhysiologyNeural control of respiratory musclesNeuromuscular control of the upper airwaysApplication of respiratory neurpohysiology to biomedical problems Selected PublicationsIizuka M, Fregosi RF. Influence of hypercapnic acidosis and hypoxia on abdominal expiratory nerve activity in the rat. Respir Physiol Neurobiol. PMID: 17292680, 2007.Van Zutphen C, Janssen P, Hassan M, Cabrera R, Bailey EF, Fregosi RF. Regional velopharyngeal compliance in the rat: influence of tongue muscle contraction. NMR Biomed. PMID: 17274106, 2007.Bailey EF, Huang YH, Fregosi RF. Anatomic consequences of intrinsic tongue muscle activation. J Appl Physiol. 101(5):1377-85, 2006.Fregosi RF, Quan SF, Morgan WL, Goodwin JL, Cabrera R, Shareif I, Fridel KW, Bootzin RR. Pharyngeal critical pressure in children with mild sleep-disordered breathing.J Appl Physiol. 101(3):734-9, 2006,Bailey EF, Fregosi RF. Modulation of upper airway muscle activities by bronchopulmonary afferents. J Appl Physiol. 101(2):609-17, 2006.Fregosi RF, Quan SF. MRI of pharyngeal airway in children with sleep-disordered breathing. J Appl Physiol. 99(6):2470; author reply 2470, 2005.John J, Bailey EF, Fregosi RF. Respiratory-related discharge of genioglossus muscle motor units. Am J Respir Crit Care Med. 172(10):1331-7, 2005.Bailey EF, Janssen PL, Fregosi RF. PO2-dependent changes in intrinsic and extrinsic tongue muscle activities in the rat. Am J Respir Crit Care Med. 171(12):1403-7, 2005.Student Opportunities Through ResearchOpportunity to attend national conferences. Research resulting in publication.Sponsored Research Through MSRPCaitlyn Harrison (MSRP 2011): "Influence of Prenatal Nicotine Exposure on the Control of Breathing"NIH High School Student Research ProgramAbdullah Aleem, Palo Verde High School, 2012

Select Publications

Wollman LBuls, Levine RB, Fregosi RF. "Developmental nicotine exposure alters glycinergic neurotransmission to hypoglossal motoneurons in neonatal rats." J. Neurophysiol.. 2018;120(3):1135-1142. PMCID: PMC6171071  PMID: 29847237
Wollman LBuls, Levine RB, Fregosi RF. "Developmental plasticity of GABAergic neurotransmission to brainstem motoneurons." J. Physiol. (Lond.). 2018. PMID: 29352468